The most dominant program in women’s college basketball history is the UConn Huskies. They’ve captured 11 national championships thus far, and are rated as the top team to win it all this season by college basketball betting sites.
Connecticut qualified for this year’s tournament as a 2-seed and is narrowly trailed in the NCAAB odds by South Carolina, which is rated 15 points behind them in the moneyline.
Women’s College Basketball National Champion 2025
- Connecticut (#2) +150
- South Carolina +165
- UCLA (#1) +650
- Texas +900
- Notre Dame +1200
- USC (#1) +2500
- TCU (#2) +3000
- Duke (#2) +3200
- LSU +4000
- Tennessee (#5) +5000
- NC State (#2) +5500
- Mississippi +7000
- Oklahoma +8000
- Kansas State (#5) +8500
- Maryland (#4) +15000
- North Carolina (#3) +15000
After UConn and South Carolina, the odds for the remaining fourteen teams drop off a nearly 500-point cliff.
The first four matchups of the Women’s Sweet 16 begin this Friday. Here are the current betting lines offered at the top March Madness sportsbook sites.
Mississippi vs. UCLA Betting Line
- Spread: Mississippi +9.0 -115, UCLA -9.0 -115
- Over: 133.5 -115
- Under: 133.5 -115
Ole Miss is a 9-point underdog to UCLA. All 1-seeds still remain in the tournament, and each one is favored to move on to the Elite 8.
Maryland vs. South Carolina Betting Line
- Spread: Maryland +17.0 -115, South Carolina -17.0 -115
- Over: 150.5 -115
- Under: 150.5 -115
The Gamecocks are also a 1-seed and are projected to blow out the #4 Maryland Terrapins.
North Carolina vs. Duke Betting Line
- Spread: North Carolina +5.5 -115, Duke -5.5 -115
- Over: 124.5 -115
- Under: 124.5 -115
This matchup of ACC elites will narrow the conference field from three to at least two teams. If NC State loses in the Round of 16, the winner will be the last ACC team standing in the tourney.
LSU vs. NC State Betting Line
- Spread: LSU -3.0 -115, NC State +3.0 -115
- Over: 153.5 -115
- Under: 153.5 -115
Neither the LSU Tigers nor the NC State Wolfpack are granted much of a chance to win the championship according to the WNCAAB futures. The betting odds for this game imply that LSU will narrowly escape NC State and advance to the Elite 8.
The following games in the Women’s bracket tip off this Saturday.
Notre Dame vs. TCU Betting Line
- Spread: Notre Dame -5.5 -115, TCU +5.5 -115
- Over: 144.5 -115
- Under: 144.5 -115
Basketball betting sites predict that the Notre Dame Fighting Irish will dispatch TCU from the Tournament this Saturday. We like TCU’s moxie and are betting on the Horned Frogs to cover against Notre Dame.
Tennessee vs. Texas Betting Line
- Spread: Tennessee +8.0 -115, Texas -8.0 -115
- Over: 155.0 -115
- Under: 155.0 -115
This All-SEC matchup favors the Texas Longhorns to best the Tennessee Volunteers by at least 8 points this weekend.
Oklahoma vs. Connecticut Betting Line
- Spread: Oklahoma +14.5, Connecticut -14.5 -115
- Over: 153.5 -115
- Under: 153.5 -115
The Huskies are the top-rated team in the nation and are favored to win the title. It should be no surprise that UConn is a heavy favorite against Oklahoma, but the large spread dares gamblers to bet on the Sooners to cover.
USC vs. Kansas State Betting Line
- Spread: USC -3.5 -115, Kansas State +3.5-115
- Over: 142.5 -115
- Under: 142.5 -115
The final matchup of the Sweet 16 features a betting line that favors the USC Trojans to get beyond K-State by 3.5 points, suggesting that this contest will come down to the wire. 2
2025 Women’s Sweet 16 Odds And Lines Provided By Bovada Sportsbook & BetUS Sportsbook